教育背景：

学      士  1983.09-1988.07   临床兽医学 中国扬州大学

硕      士  1988.09-1991.06   预防兽医学 中国扬州大学

博      士  2002.01-2005.12   感染与免疫 英国剑桥大学

工作经历：

全日职务

助          教   1991.09-1994.08     中国扬州大学

讲          师   1994.09-1999.04     中国扬州大学

教          授   2003.09-2005.12     中国扬州大学

访 问 学 者   1999.05-2000.08   英国剑桥大学

兼职研究员   2001.01-2003.12  英国动物健康研究所                    

助理研究员   2001.01-2003.12   英国剑桥大学

副 研 究 员   2006.01-2009.02   英国剑桥大学

研  究   员   2009.03-2013.02   英国剑桥大学

高级研究员   2013.03-2018.06   英国剑桥大学  (终身)

教          授   2018.06 至今         中国山西大学

访问研究员   2018.06至今           英国剑桥大学医学系和兽医学系

行政任职：

实验室副主任  2009.03-2015.05   英国剑桥大学医学系人类疾病遗传学实验室  创始人

院             长  2015.06至今         中国山西大学生物医学研究院  院长  创始人

研究领域：

      吴长新教授主要从事感染与免疫和人类疾病遗传学基础研究，聚焦地域性重大疾病病理机制与新干预技术研究。回国前后主持和参与国家基金项目、国家973项目、国家支撑计划、国家重点科技计划、Wellcome Trust、英国生物技术理事会和欧盟第七框架重大项目等项目。有关感染与免疫方面的主要科学与学术成就在《科学》、《自然》和《美国科学院学报》等期刊发表。获得Wellcome Trust国际青年科学家发展奖荣誉和剑桥大学海外奖学金委员会终生荣誉会员。

      在英国剑桥大学学习和工作近二十年后，应山西大学邀请，在山西省海外高层次人才、 山西省高层次引进人才创新团队、和山西省“三晋英才”支持计划等人才支持计划资助下，辞去剑桥大学工作职位，担任剑桥大学访问科学家，2018年正式加盟山西大学，组建山西大学生物医学研究员，担任生物医学研究院院长和人类重要疾病病理机制与新干预技术团队首席科学家，此后兼任剑桥大学医学院和兽医学院终身访问研究员。目前担任并山西省特聘专家、山西省干细胞产业创新联盟理事长、山西省生物工程学会常务理事、中国防痨协会标准委员会常务委员和山西省战略科学家。

主要文章：

1、Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation. Cuchet-Louren？o D#, Eletto D#, Wu C#, Plagnol V, Papapietro O, Curtis J, Ceron-Gutierrez L, Bacon CM, Hackett S, Alsaleem B, Maes M, Gaspar M, Alisaac A, Goss E, AlIdrissi E, Siegmund D, Wajant H, Kumararatne D, AlZahrani MS, Arkwright PD, Abinun M, Doffinger R, Nejentsev S* . Science. 2018 Aug 24;361(6404):810-813. doi: 10.1126/science.aar2641. Epub 2018 Jul 19..

2、Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration. Curtis J, Luo Y, Zenner HL, Cuchet-Louren D, Wu C, Lo K, Maes M, Alisaac A, Stebbings E, Liu JZ, Kopanitsa L, Ignatyeva O, Balabanova Y, Nikolayevskyy V, Baessmann I, Thye T, Meyer CG, Nürnberg P, Horstmann RD, Drobniewski F, Plagnol V, Barrett JC, Nejentsev S. Nat Genet. 2015 May;47(5):523-527. doi: 10.1038/ng.3248. Epub 2015 Mar 16.

3、Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage. Angulo I, Vadas O, Gar？on F, Banham-Hall E, Plagnol V, Leahy TR, Baxendale H, Coulter T, Curtis J, Wu C, Blake-Palmer K, Perisic O, Smyth D, Maes M, Fiddler C, Juss J, Cilliers D, Markelj G, Chandra A, Farmer G, Kielkowska A, Clark J, Kracker S, Debré M, Picard C, Pellier I, Jabado N, Morris JA, Barcenas-Morales G, Fischer A, Stephens L, Hawkins P, Barrett JC, Abinun M, Clatworthy M, Durandy A, Doffinger R, Chilvers ER, Cant AJ, Kumararatne D, Okkenhaug K, Williams RL, Condliffe A, Nejentsev S. Science. 2013 Nov 15;342(6160):866-71. doi: 10.1126/science.1243292. Epub 2013 Oct 17.

4、Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression. Goodall JC#, Wu C#, Zhang Y, McNeill L, Ellis L, Saudek V, Gaston JS. Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17698-703. doi: 10.1073/pnas.1011736107. Epub 2010 Sep 27.

5. RNA seq and quantitative proteomic analysis of Dictyostelium knock-out cells lacking the core autophagy proteins ATG9 and/or ATG16. Qiuhong Xiong, Ning Song , Ping Li, Sarah Fischer , Roman Konertz , Prerana Wagle , Gernot Glöckner , Changxin Wu , Ludwig Eichinger. BMC Genomics. 2021 Jun 15;22(1):444. doi: 10.1186/s12864-021-07756-2.

6. ASAP1 regulates the uptake of Mycobacterium tuberculosis H37Ra in THP1-derived macrophages by remodeling actin cytoskeleton. Jia Cui, Guangxin Chen , Zhonghua Zhao, Liqing Wang , Da Wen , Li Xing , Changxin Wu. Tuberculosis (Edinb) . 2021 May 26;129:102090.  doi: 10.1016/j.tube.2021.102090. Online ahead of print.

7. Identification of Two Novel Compound Heterozygous EIF2AK3 Mutations Underlying Wolcott–Rallison Syndrome in a Chinese Family Front. Na Zhao, Yanling Yang, Ping Li1, Qiuhong Xiong, Han Xiao and Changxin Wu. Pediatr., 26 May 2021 https://doi.org/10.3389/fped.2021.679646

8. Polydatin has anti-inflammatory and antioxidant effects in LPS-induced macrophages and improves DSS-induced mice colitis. Guangxin Chen, Ziyue Yang, Da Wen, Jian Guo, Qiuhong Xiong, Ping Li, Liping Zhao, Junping Wang, Changxin Wu, Lina Dong. Immun Inflamm Dis. 2021 May 19. doi: 10.1002/iid3.455. Online ahead of print.

9. Microbiota and Tuberculosis: A Potential Role of Probiotics, and Postbiotics. Front Nutrition. Yue Liu, Jiaqi Wang, Changxin Wu. 2021 May 7;8:626254. doi: 10.3389/fnut.2021.626254. eCollection 2021.

10. Progressive liver injury and increased mortality risk in COVID-19 patients: A retrospective cohort study in China. Shui-Sheng Zhang, Li Dong, Gao-Ming Wang, Yuan Tian, Xiao-Fang Ye, Yue Zhao, Zheng-Yin Liu, Jia-Yu Zhai, Zhi-Ling Zhao, Jun-Hong Wang, Hui-Min Zhang, Xiao-Long Li, Chang-Xin Wu, Cai-Ting Yang, Li-Juan Yang, Hai-Xia Du, Hui Wang, Qing-Gang Ge, Dian-Rong Xiu, Ning Shen. World J Gastroenterol. 2021 Mar 7;27(9):835-853. doi: 10.3748/wjg.v27.i9.835.

11、WDR45 Mutation Impairs the Autophagic Degradation of Transferrin Receptor and Promotes Ferroptosis. Qiuhong Xiong*, Xin Li, Wenjing Li, Guangxin Chen, Han Xiao, Ping Li* and Changxin Wu*. .Front. Mol. Biosci., 03 May 2021 | https://doi.org/10.3389/fmolb.2021.645831

12、The negative charge of the 343 site is essential for maintaining physiological functions of CXCR4. Wang L , Xiong Q , Li P , Chen X , Tariq N , Wu C. BMC Mol Cell Biol . 2021 Jan 23;22(1):8. doi: 10.1186/s12860-021-00347-9.

13、Generation of Dip2a homozygous knockout murine ES cell line IBMSe001-A-1 via CRISPR/Cas9 technology. Yao M, Yang Q, Lian M, Su P, Cui X, Ren T, Wang X, Wu C,Zheng Y.Stem Cell Res. 2020 May;45:101778. doi: 10.1016/j.scr.2020.101778. Epub 2020 Mar 19.

14、The Role of ATG16 in Autophagy and The Ubiquitin Proteasome System. Xiong Q, Li W, Li P, Yang M, Wu C, Eichinger L. Cells. 2018 Dec 20;8(1):2. doi: 10.3390/cells8010002.

15、Asap1 Affects the Susceptibility of Zebrafish to Mycobacterium by Regulating Macrophage Migration. Cui J , Chen G, Wen D , Wang Y, Zhao Z , Wu C. Front Cell Infect Microbiol. 2020 Oct 29;10:519503. doi: 10.3389/fcimb.2020.519503. eCollection 2020.

16、Bayesian phylodynamic inference on the temporal evolution and global transmission of SARS-CoV-2. Li J, Li Z , Cui X, Wu C. J Infect. 2020 Aug;81(2):318-356. doi: 10.1016/j.jinf.2020.04.016. Epub 2020 Apr 20.

17、Identification and spatiotemporal expression of gpr161 genes in zebrafish. Wang M , Li P , Wang H , Dong L , Wu C , Zhao Z. Gene. 2020 Mar 10;730:144303. doi: 10.1016/j.gene.2019.144303. Epub 2019 Dec 26.

18、Bacteria Exploit Autophagy For Their Own Benefit. Xiong Q, Yang M , Li P , Wu C. Infect Drug Resist. 2019 Oct 11;12:3205-3215. doi: 10.2147/IDR.S220376. eCollection 2019.

19、Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration.Curtis J, Luo Y, Zenner HL, Cuchet-Louren？o D, Wu C, Lo K, Maes M, Alisaac A, Stebbings E, Liu JZ, Kopanitsa L, Ignatyeva O, Balabanova Y, Nikolayevskyy V, Baessmann I, Thye T, Meyer CG, Nürnberg P, Horstmann RD, Drobniewski F, Plagnol V, Barrett JC, Nejentsev S. Nat Genet. 2015 May;47(5):523-527. doi: 10.1038/ng.3248. Epub 2015 Mar 16.

20、Functional evaluation of a novel GLA causative mutation in Fabry disease. Li P, Zhang L, Xiong Q, Wang Z, Cui X, Zhou YA, Wang Y, Xiao H, Wu C. Mol Genet Genomic Med. 2019 Sep;7(9):e864. doi: 10.1002/mgg3.864. Epub 2019 Jul 18.

21、A Novel α-Galactosidase A Splicing Mutation Predisposes to Fabry Disease. Li P, Zhang L, Zhao N, Xiong Q, Zhou YA, Wu C*, Xiao H*. Front Genet. 2019 Feb 11;10:60. doi: 10.3389/fgene.2019.00060. eCollection 2019.

22、Altered gut metabolome contributes to depression-like behaviors in rats exposed to chronic unpredictable mild stress. Jianguo L, Xueyang J, Cui W, Changxin W, Xuemei Q. Transl Psychiatry. 2019 Jan 29;9(1):40. doi: 10.1038/s41398-019-0391-z

23、Altered gut metabolome contributes to depression-like behaviors in rats exposed to chronic unpredictable mild stress. Jianguo L, Xueyang J, Cui W, Changxin W, Xuemei Q. Transl Psychiatry. 2019 Jan 29;9(1):40. doi: 10.1038/s41398-019-0391-z.

24、The Role of ATG16 in Autophagy and The Ubiquitin Proteasome System. Xiong Q, Li W, Li P, Yang M, Wu C, Eichinger L. Cells. 2018 Dec 20;8(1). pii: E2. doi: 10.3390/cells8010002. Review.

25、Short Term Intrarectal Administration of Sodium Propionate Induces Antidepressant- Like Effects in Rats Exposed to Chronic Unpredictable Mild Stress.Li J, Hou L, Wang C, Jia X, Qin X, Wu C. Front Psychiatry. 2018 Sep 27;9:454. doi: 10.3389/fpsyt.2018.00454. eCollection 2018.

26、Functional evidence for a de novo mutation in WDR45 leading to BPAN in a Chinese girl. Xiong Q, Li W, Li P, Zhao Z, Wu C, Xiao H. Mol Genet Genomic Med. 2019 Sep;7(9):e858. doi: 10.1002/mgg3.858. Epub 2019 Jul 22.

27、A novel de novo mutation in COL2A1 leading to spondyloepiphyseal dysplasia congenita in a Chinese family. Xiong Q, Liu Y, Xue Y, Liu S, Wang J, Li P, Wu C, Yang Y, Xiao H. Hum Genome Var. 2018 Jan 11;5:17059. doi: 10.1038/hgv.2017.59. eCollection 2018.

28、Whole-exome sequencing analysis of Waardenburg syndrome in a Chinese family.Chen D, Zhao N, Wang J, Li Z, Wu C, Fu J, Xiao H. Hum Genome Var. 2017 Jun 29;4:17027. doi: 10.1038/hgv.2017.27. eCollection 2017.

29、Resveratrol Induces Cancer Cell Apoptosis through MiR-326/PKM2-Mediated ER Stress and Mitochondrial Fission. Wu H, Wang Y, Wu C, Yang P, Li H, Li Z. J Agric Food Chem. 2016 Dec 14;64(49):9356-9367. Epub 2016 Dec 5.

30、MiR-106b-mediated Mfn2 suppression is critical for PKM2 induced mitochondrial fusion. Wu H, Li Z, Wang Y, Yang P, Li Z, Li H, Wu C. Am J Cancer Res. 2016 Oct 1;6(10):2221-2234. eCollection 2016.

31、Sildenafil potentiates bone morphogenetic protein signaling in pulmonary arterial smooth muscle cells and in experimental pulmonary hypertension. Yang J, Li X, Al-Lamki RS, Wu C, Weiss A, Berk J, Schermuly RT, Morrell NW. Arterioscler Thromb Vasc Biol. 2013 Jan;33(1):34-42. doi: 10.1161/ATVBAHA.112.300121. Epub 2012 Nov 8.

32、Mapping and characterization of visna/maedi virus cytotoxic T-lymphocyte epitopes. Wu C, Barbezange C, McConnell I, Blacklaws BA. J Gen Virol. 2008 Oct;89(Pt 10):2586-96. doi: 10.1099/vir.0.2008/002634-0.

33、Cloning and characterization of ovine beta2-microglobulin cDNAs. Wu C, McConnell I, Blacklaws B. Vet Immunol Immunopathol. 2008 Jun 15;123(3-4):360-5. doi: 10.1016/j.vetimm.2008.02.017. Epub 2008 Mar 4.