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张永斌

信息来源:发布时间:2023-11-08

张永斌,男,19804月生,山西大同人。博士,教授,博士生导师,山西省化学会副秘书长,山西省三晋英才”优秀青年人才,化学生物学与分子工程教育部重点实验室副主任。

2003年毕业于山西大学化学化工学院获理学学士学位,同年考入山西大学有机化学专业攻读硕士学位,2006年硕士研究生毕业留校任教,在应用化学研究所工作。2015年在山西大学有机化学专业获理学博士学位。主要从事与疾病相关的化学小分子标志物的荧光检测与生物成像研究工作。主持国家自然科学基金面上项目2项、山西省自然科学基金1项,参与多项国家级和省级科研项目,在J. Am. Chem. Soc., Sens. Actuators B, Chinese Chem. Lett.等期刊发表SCI论文20多篇,获得授权发明专利7项。作为主要完成人,获山西省自然科学三等奖1项,山西省科技进步二等奖1项。

主持科研项目

1. 国家自然科学基金面上项目,22377072,基于氟硼二吡咯大Stokes位移NIR荧光探针肿瘤成像研究,2024/01-2027/12

2. 国家自然科学基金面上项目,21672131,用于区分识别CysHcyGSH多结合位点荧光探针的设计及生物传感应用,2017/01-2020/12

3. 山西省自然科学基金项目,2012011046-14,手性N-杂环卡宾金属化合物的合成及其催化不对称反应研究,2012/01-2014/12

代表性论文

1. Zhuo Wang, Jinping Jia, Fangjun Huo, Yongbin Zhang*, Jianbin Chao*, A fluorescent probe for monitoring Cys fluctuations in the oxidative stress environment simulated by Cu2+ or H2O2, Bioorganic Chemistry, 2022, 120, 105618.

2. Yongbin Zhang, Yu Zhang, Yongkang Yue, Jianbin Chao, Fangjun Huo, Caixia Yin*, A special o-dialdehyde fluorescent probe simultaneously sensing Hcy, GSH and its application in living cells and zebrafish imaging, Chinese Chemical Letters, 2021, 32, 2873-2876.

3. Yongbin Zhang, Le Wen, Weijie Zhang, Yongkang Yue, Jianbin Chao, Fangjun Huo, Caixia Yin*, Sulphide activity-dependent multicolor emission dye and its applications in in vivo imaging, Analyst, 2021, 146, 5517-5527.

4. Yongbin Zhang, Yu Zhang, Yongkang Yue, Jianbin Chao, Fangjun Huo, Caixia Yin*, Based on morpholine as luminescence mechanism regulation and organelle targeting dual function Cys NIR specific biological imaging probe, Sensors and Actuators B: Chemical, 2020, 320, 128348.

5. Yongfei Huang, Yongbin Zhang, Fangjun Huo, Jianbin Chao, Fangqin Cheng*, Caixia Yin*, A new strategy: distinguishable multi-substance detection, multiple pathway tracing based on a new site constructed by the reaction process and its tumor targeting, Journal of the American Chemical Society, 2020, 142, 18706-18714.

6. Yongbin Zhang, Jianfen Wang, Yongkang Yue, Jianbin Chao, Fangjun Huo, Caixia Yin*, A new strategy for the fluorescence discrimination of Cys/Hcy and GSH/H2S simultaneously colorimetric detection for H2S, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2020, 227, 117537.

7. Yongbin Zhang, Yongfei Huang, Yongkang Yue, Jianbin Chao, Fangjun Huo, Caixia Yin*, A compact fluorescent probe based on o-phthalaldehyde for ultrasensitive detection of hydrazine in gas and solution phases, Sensors and Actuators B: Chemical, 2018, 273, 944-950.

8. Yongbin Zhang, Fangjun Huo, Caixia Yin*, Yongkang Yue, Junsheng Hao, Jianbin Chao, Diansheng Liu*, An off–on fluorescent probe based on maleimide for detecting thiols and its application for bioimaging, Sensors and Actuators B: Chemical, 2015, 207, 59-65.

9. Yongbin Zhang, Yutao Yang, Junsheng Hao, Caixia Yin*, Fangjun Huo, Jianbin Chao, Diansheng Liu*, Spectroscopic study of the recognition of 2-quinolinone derivative on mercury ion, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2014, 132, 27-31.

10. Yongbin Zhang, Jianbin Chao*, Shuhui Zhao, Penghao Xu, Hongfang Wang, Zhiqiang Guo, Diansheng Liu*, Investigation on the inclusion interaction of 4-sulfonatocalix[n]arenes with 1-(4-nitrophenyl) -piperazine, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2014, 132, 44-51.

授权发明专利

1. 张永斌,张瑜,钞建宾,郝俊生,霍方俊,阴彩霞,一种溶酶体靶向的Cys近红外荧光探针及其制备方法和应用,2022-3-18,中国,ZL202010236462.9

2. 张永斌,段月香,王娟娟,钞建宾,一种荧光探针HM及其制备方法和应用,2022-3-18,中国,ZL202011623148.2

3. 张永斌,黄永飞,钞建宾,霍方俊,阴彩霞,一种用于检测水合肼的荧光探针及其制备方法和应用,2020-4-17,中国,ZL201810073175.3

4. 张永斌,张芳琴,钞建宾,童红波,袁世芳,白生弟,刘滇生,NO-双负离子配位的锆金属化合物及其制备方法和应用,2017-12-05,中国,ZL201510762766.8

5. 张永斌,钞建宾,郝俊生,一种吡唑并吡啶衍生物及其制备方法和应用,2016-11-30,中国,ZL201510762749.4

6. 张永斌,魏学红,郝俊生,郭志强,钞建宾,刘滇生,一种手性吡咯烷功能化的咪唑盐及其制备方法和应用,2015-5-13,中国,ZL201310533308.8

7. 张永斌,郝俊生,霍方俊,阴彩霞,钞建宾,刘滇生,一种2-喹啉酮类化合物及其制备方法和应用,2015-4-15,中国,ZL 201310533310.5

联系方式

地址:山西省太原市坞城路92号,山西大学应用化学研究所

邮编:030006

邮箱:zhangyb@sxu.edu.cn